Genome wide in silico SNP-tumor association analysis
نویسندگان
چکیده
منابع مشابه
SNP Set Association Analysis for Genome-Wide Association Studies
Genome-wide association study (GWAS) is a promising approach for identifying common genetic variants of the diseases on the basis of millions of single nucleotide polymorphisms (SNPs). In order to avoid low power caused by overmuch correction for multiple comparisons in single locus association study, some methods have been proposed by grouping SNPs together into a SNP set based on genomic feat...
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Genome-wide association studies (GWAS) are popular for identifying genetic variants which are associated with disease risk. Many approaches have been proposed to test multiple single nucleotide polymorphisms (SNPs) in a region simultaneously which considering disadvantages of methods in single locus association analysis. Kernel machine based SNP set analysis is more powerful than single locus a...
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The power of genome-wide SNP association studies is limited, among others, by the large number of false positive test results. To provide a remedy, we combined SNP association analysis with the pathway-driven gene set enrichment analysis (GSEA), recently developed to facilitate handling of genome-wide gene expression data. The resulting GSEA-SNP method rests on the assumption that SNPs underlyi...
متن کاملAn overview of SNP interactions in genome-wide association studies.
With the recent explosion in high-throughput genotyping technology, the amount and quality of single-nucleotide polymorphism (SNP) data has increased exponentially. Therefore, the identification of SNP interactions that are associated with common diseases is playing an increasing and important role in interpreting the genetic basis of disease susceptibility and in devising new diagnostic tests ...
متن کاملGenome-wide association analysis
Genome-wide association (GWA) studies have become overwhelmingly popular in the last few years as a means to elucidate associations between particular alleles in one’s DNA and a predisposition to disease, using genetic data from unrelated individuals randomly sampled from a population (Balding, 2006; WTCCC, 2007). The recent availability of large amounts of such population genetic data necessit...
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ژورنال
عنوان ژورنال: BMC Cancer
سال: 2004
ISSN: 1471-2407
DOI: 10.1186/1471-2407-4-4